PDRN (polydeoxyribonucleotide) is the new K beauty skincare ingredient in town and here's why we love it

Polydeoxyribonucleotide, or PDRN, is making waves in the world of K-beauty, emerging as the latest “it” ingredient that promises skin repair, hydration, and rejuvenation in one go. Extracted from salmon DNA, PDRN is not just another trendy ingredient but a scientifically backed regenerative compound that’s moving from Korean skincare routines into advanced skin clinics globally, including in India.

“PDRN isn’t just another trend, I believe it is here to stay,” says Dr Chiranjiv Chhabra, chief dermatologist and founder, Alive Wellness Clinics. “Think of it as a multitasking skin saviour working simultaneously to repair, hydrate, and rejuvenate skin.”

The science behind PDRN

Originally used in wound healing and orthopaedics, PDRN is a naturally occurring DNA fragment known for its remarkable ability to stimulate tissue repair and regeneration. It works by promoting fibroblast activity, which helps produce collagen and elastin, and has anti-inflammatory properties that support post-inflammatory hyperpigmentation (PIH) and healing.

“PDRN is a potent, well-researched ingredient that deserves a spot in modern skincare, especially when paired with good sun protection and a holistic approach,” explains Dr Mikki Singh, board-certified dermatologist and cosmetologist, founder and medical director, Bodycraft Clinics. “It enhances the skin’s natural moisture barrier, making it a great companion to hyaluronic acid, and since it’s bio-compatible and non-irritating, it’s safe for deeper skin tones and sensitive skin.”

Why Is PDRN gaining popularity in K-beauty and clinics?

In Korean skincare, PDRN has seamlessly integrated into serums, creams, and injectable skin boosters due to its ability to accelerate skin recovery and boost overall glow. From post-procedure redness to everyday dullness and fine lines, PDRN is proving to be a quiet yet powerful ingredient that supports skin healing and rejuvenation from within.

“We’ve seen remarkable results using PDRN treatment, especially for speeding up recovery after microneedling, lasers, or chemical peels,” adds Dr Chhabra. “It reduces redness and brings a healthy glow much faster than traditional post-care products.”

Why beauty experts are calling it a “game-changer”

“I’m the chief tester at kindlife, and while I’ve tried more actives than I can count, Polydeoxyribonucleotide is a true star,” says Ms Radhika Ghai, founder and CEO, kindlife. “Korea was quick to recognise its potential, and today, it's at the heart of some of the most effective skin-healing treatments. Unlike trendy ingredients that fade fast, PDRN actually rebuilds and restores the skin from within.”

With brands making PDRN-infused products accessible in India, entire skincare routines are now being built around this ingredient, making regenerative skincare easier to incorporate into your daily life.

Is PDRN worth the hype?

If your skin is struggling with dullness, sensitivity, or early signs of ageing, PDRN is worth considering under professional guidance. It isn’t a miracle ingredient, but it is a reliable, research-backed addition that can help improve skin elasticity, strengthen the skin barrier, and give you a brighter, youthful glow over time.

As Dr Chhabra concludes, “Whether you’re dealing with post-procedure redness, everyday dryness, or those fine lines that seem to appear overnight, PDRN quietly gets to work behind the scenes and makes sure you shine on centre stage.”

Lead image: Pexels
 

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