A formula-forward approach to skincare, through the lens of iS Clinical

Finding a permanent place in a skincare routine is easier said than done, but a scientifically advanced approach can make all the difference. Only a few brands embody this philosophy as effectively as iS Clinical. Founded in 2000, the American skincare powerhouse offers products you find yourself coming back to time and again. Driven by the vision of co-founders Bryan Johns and Alec Call to elevate the physical and emotional well-being of people, the brand’s efficacy lies in the fact that it bridges the gap between science and beauty.

The foundation of iS Clinical is its product formulation & Extremozyme technology, meticulously formulated using the most advanced technologies available, by a global team of experts, to ensure they are dramatically effective and aesthetically elegant. They use pharmaceutical-grade ingredients and botanically sourced ingredients to ensure their formulas are not only powerful and efficacious, but also gentle, non- irritating, and easy to use.

“To ensure formulation precision and unparalleled quality, we create formulas in our labs and manufacture at our facilities. This is the key to superior product efficacy that delivers proven results again and again. That will always be a main differentiator for us,” says Bryan Johns, CEO and Co-founder, iS Clinical. Through a network of dermatologists, cosmetic surgeons, medical spas, and skincare professionals across more than 125 countries, iS Clinical has carved a noteworthy niche for itself in skin health. From its cult-classic Active Serum and the rich Youth Intensive Crème to the Cleansing Complex, the brand has built an impressive repertoire of products that continue to resonate with both skincare experts and beauty enthusiasts around the world today.

This article originally appeared in Harper's Bazaar India's June-July 2026 print issue.

Image credits: Courtesy the brand 

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